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Welcome to the Koutmou Lab

 

Research

Unlocking the Mysteries of the Ribosome

 
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mRNA modifications

Chemical modifications to mRNAs change the topologies and chemistries accessible to these biomolecules, potentially altering their biogenesis, localization, function, and stability. The Koutmou laboratory is working to ascertain how mRNA modifications impact protein synthesis. We are tackling this challenge from two perspectives: from the level of the modification itself (how, where, and which modifications are incorporated), and from the viewpoint of the ribosome which ‘reads’ the modification.

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Translational control

The ribosome is the molecular machine responsible for translating mRNA into protein. The Koutmou lab uses fully-reconstituted in vitro and cell-based approaches to take a molecular level look at how mRNA and nascent peptide, and chemical modification of the translation machinery control protein production.

People

A Collaborative & Diverse Group

Dr. Daniel Eyler

Lab Manager

B.S. Biochemistry, Georgetown University 
Ph.D. Biochemistry, Johns Hopkins School of Medicine
Post-doc, Biological Chemistry, University of Michigan

Dr. Kristin Koutmou

Principle Investigator

B.S. Chemistry, University of Colorado at Denver
Ph.D. Chemistry, University of Michigan
Post-doc, Molecular Biology and Genetics, Johns Hopkins School of Medicine

Dr. Mehmet Tardu

Post-Doc

B.S. Molecular Biology and Genetics, Bogazici University
Ph.D. Computational Science and Engineering, Koc University

Monika Franco

Ph.D. student, Program in Chemical Biology

B.S. Chemistry, Wayne State University

Luke Miller

Ph.D. student, Program in Chemical Biology

B.S. Chemistry, Hillsdale College

Meredith Purchal

Ph.D. student, Program in Chemical Biology

B.S. Biology, University of Texas

Tyler Smith

Ph.D. student - Chemistry

B.S. Chemistry and Biology, Truman State University

Olivia Bachteal

Undergraduate researcher

Biochemistry major

Ryan McNassor

Undergraduate researcher

Biochemistry major

Joshua Jones

Rotation graduate student, Chemistry

B.S. Chemical Engineering, University of Illinois at Urbana-Champaign

Jeremy Monroe

Rotation graduate student, Chemistry

B.S. Chemistry, SUNY Stony Brook

Claire Neice

Rotation graduate student, Chemistry

B.S. Chemistry, Virginia Tech

 

Contact Us

Department of Chemistry
930 N University Ave
Ann Arbor, MI 48109
Lab: Chemistry 2050
Office: Chemistry 2549

734-764-5650

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