IMG_2125.JPG
 

2021

METHYLATED GUANOSINE AND URIDINE MODIFICATIONS IN S. CEREVISIAE MRNAS MODULATE TRANSLATION

JD Jones, MK Franco, TJ Smith, LR Snyder, RT Kennedy, KS Koutmou

submitted

2021

CHEMICAL MODIFICATIONS TO MRNA NUCLEOBASES IMPACT TRANSLATION ELONGATION AND TERMINATION

MK Franco, KS Koutmou

submitted

2021

SEQUENCE AND MODIFICATION STATUS OF RNAS IN THE TRANSLATION MACHINERY DIRECT RIBOSOME MOVEMENTS DURING THE SYNTHESIS OF POLY(LYSINE) ENCODING PEPTIDES

TJ Smith, M Tardu, KS Koutmou

submitted

2021

SUPPORTING STUDENT LEARNING IN BIOCHEMISTRY USING A SCIENCE COMMUNICATION FOCUSED WRITING ASSIGNMENT

SA Finkenstaedt-Quinn, NF Garza, CA Wilhelm, KS Koutmou, GV Shultz

submitted

2021

THE CAMP SIGNALING PATHWAY REGULATES EPE1 PROTEIN LEVELS AND HETEROCHROMATIN ASSEMBLY

S Jia, K Bao, CM Shan, X Chen, G Raiymbek, JG Monroe, KS Koutmou, K Ragunathan, C Lu, L Berchowitz

under revision

2021

PSEUDOURIDINE SYNTHASE 7 IS AN OPPORTUNISTIC ENZYME THAT BINDS AND MODIFIES SUBSTRATES WITH DIVERSE SEQUENCES AND STRUCTURES

MK Purchal, DE Eyler, M Tardu, MK Franco, MM Korn, T Khan, R McNassor, R Giles, K Lev, H Sharma,  J Monroe, L Mallik, M Koutmos, KS Koutmou

PNAS, in press

2021

IN VITRO INVESTIGATION OF TRANSLATIONAL FIDELITY ON MODIFIED CODONS

JG Monroe, TJ Smith, KS Koutmou

Methods Enzymology (DOI: 10.1016/bs.mie.2021.06.011)

2021

COMMUNICATING SCIENCE TO THE GENERAL PUBLIC THROUGH A BIOCHEMISTRY WRITING ASSIGNMENT

Garza N, Finkenstaedt-Quinn S, Wilhelm, C, Koutmou K, Shultz G

Journal of Chemical Education (DOI: 10.1021/acs.jchemed.0c01176)

2020

A MOLECULAR LEVEL PERSPECTIVE ON THE FREQUENCY, DISTRIBUTION AND POSSIBLE CELLULAR ROLES OF MRNA MODIFICATIONS

JD Jones, J Monroe and KS Koutmou

WIREs RNA (DOI: 10.1002/wrna.1586)

2019

PSEUDOURIDINYLATION OF MRNA CODING SEQUENCES ALTERS TRANSLATION

DE Eyler, MK Franco, Z Batool, MZ Wu, ML Debuke, M Dobosz-Bartoszek, JD Jones, Y Polikanov, B Roy, KS Koutmou

PNAS (DOI: 10.1073/pnas.1821754116)

2019

IDENTIFICATION AND QUANTIFICATION OF MODIFIED NUCLEOSIDES IN SACCHAROMYCES CEREVISIAE MRNAS

M Tardu, JD Jones, RT Kennedy, Q Lin, KS Koutmou

ACS Chemical Biology (DOI: 10.1021/acschembio.9b00369)

2015

SYNTHESIS AT THE SPEED OF CODONS

KS Koutmou, A Radhakrishnan, R Green

Trends in Biomedical Sciences

2015

TRANSLATIONAL CONTROL BY LYSINE-ENCODING A-RICH SEQUENCES

L Arthur, S Pavlovic-Djuranovic, KS Koutmou, R Green, P Szczesny, S Djuranovic

Science Advances

2015

SID-1 EXTRACELLULAR DOMAIN SELECTIVELY BINDS LONG DSRNA AND IS REQUIRED FOR RNA TRANSPORT BY SID-1

W Li, KS Koutmou, DJ Leahy, M Li

Journal of Biological Chemistry

2015

RIBOSOMES SLIDE ON LYSINE-ENCODING HOMOPOLYMERIC A STRETCHES

KS Koutmou, AP Schuller, JL Brunelle, A Radhakrishnan, S Djuranovic, R Green

eLife

2014

RF3:GTP PROMOTES RAPID DISSOCIATION OF THE CLASS 1 TERMINATION FACTOR

KS Koutmou, ME McDonald, JL Brunelle, R Green

RNA

2011

THE RNR MOTIF OF B. SUBTILIS RNASE P PROTEIN INTERACTS WITH BOTH PRNA AND PRE-TRNA TO STABILIZE AN ACTIVE CONFORMER

KS Koutmou, JJ Day-Storms, CA Fierke

RNA

2010

A DIVALENT CATION STABILIZES THE ACTIVE CONFORMATION OF THE B. SUBTILIS RNASE P•PRE-TRNA COMPLEX: A ROLE FOR AN INNER-SPHERE METAL ION IN RNASE P

J Hsieh, KS Koutmou, D Rueda, M Koutmos, NG Walter, CA Fierke

Journal of Molecular Biology

2010

NMR AND XAS REVEAL AN INNER-SPHERE METAL BINDING SITE IN THE P4 HELIX OF THE METALLO-RIBOZYME RIBONUCLEASE P

KS Koutmou, A Casiano-Negroni, M Getz, S Paczini, AJ Andrews, JE Penner-Hahn, HM Al-Hashimi, CA Fierke

Proceedings of the National Academy of Sciences

2010

PROTEIN–PRECURSOR TRNA CONTACT LEADS TO SEQUENCE-SPECIFIC RECOGNITION OF 5′ LEADERS BY BACTERIAL RIBONUCLEASE P

KS Koutmou, NH Zahler, JC Kurz, FE Campbell, ME Harris, CA Fierke

Journal of Molecular Biology

2009

KINETIC MECHANISM OF BACTERIAL RNASE P

KS Koutmou, J Hsieh, CA Fierke

Protein Reviews, Volume 10: Ribonuclease P (book chapter)

IMPORTANCE OF RNA-PROTEIN INTERACTIONS IN BACTERIAL RIBONUCLEASE P STRUCTURE AND CATALYSIS

2007

JK Smith, J Hsieh, CA Fierke

Biopolymers