Chemical modifications to mRNA nucleobases impact translation elongation and termination
2022
MK Franco and KS Koutmou
Biophysical Chemistry, in press
The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly
2022
S Jia, K Bao, CM Shan, X Chen, G Raiymbek, JG Monroe, KS Koutmou, K Ragunathan, C Lu, L Berchowitz
PLoS Genetics, in press
Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures
2022
MK Purchal, DE Eyler, M Tardu, MK Franco, MM Korn, T Khan, R McNassor, R Giles, K Lev, H Sharma, J Monroe, L Mallik, M Koutmos, KS Koutmou
PNAS (DOI: 10.1073/pnas.2109708119)
Sequence and modification status of RNAs in the translation machinery direct ribosome movements during the synthesis of poly(lysine) encoding peptides
2022
TJ Smith, M Tardu, KS Koutmou
under revision
Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation
2022
JD Jones, MK Franco, TJ Smith, LR Snyder, RT Kennedy, KS Koutmou
under revision
Supporting student learning in biochemistry using a science communication focused writing assignment
2022
SA Finkenstaedt-Quinn, NF Garza, CA Wilhelm, KS Koutmou, GV Shultz
submitted
In vitro investigation of translational fidelity on modified codons
2021
JG Monroe, TJ Smith, KS Koutmou
Methods Enzymology (DOI: 10.1016/bs.mie.2021.06.011)
Communicating science to the general public through a biochemistry writing assignment
2021
Garza N, Finkenstaedt-Quinn S, Wilhelm, C, Koutmou K, Shultz G
Journal of Chemical Education (DOI: 10.1021/acs.jchemed.0c01176)
A molecular level perspective on the frequency, distribution and possible cellular roles of mRNA modifications
2020
JD Jones, J Monroe and KS Koutmou
WIREs RNA (DOI: 10.1002/wrna.1586)
Pseudouridinylation of mRNA coding sequences alters translation
2019
DE Eyler, MK Franco, Z Batool, MZ Wu, ML Debuke, M Dobosz-Bartoszek, JD Jones, Y Polikanov, B Roy, KS Koutmou
PNAS (DOI: 10.1073/pnas.1821754116)
Identification and quantification of modified nucleosides in Saccharomyces cerevisiae mRNAs
2019
M Tardu, JD Jones, RT Kennedy, Q Lin, KS Koutmou
ACS Chemical Biology (DOI: 10.1021/acschembio.9b00369)
Synthesis at the speed of codons
2015
KS Koutmou, A Radhakrishnan, R Green
Trends in Biomedical Sciences
Translational control by lysine-encoding A-rich sequences
2015
L Arthur, S Pavlovic-Djuranovic, KS Koutmou, R Green, P Szczesny, S Djuranovic
Science Advances
SID-1 extracellular domain selectively binds long dsRNA and is required for RNA transport by SID-1
2015
W Li, KS Koutmou, DJ Leahy, M Li
Journal of Biological Chemistry
Ribosomes slide on lysine-encoding homopolymeric A stretches
2015
KS Koutmou, AP Schuller, JL Brunelle, A Radhakrishnan, S Djuranovic, R Green
eLife
RF3:GTP promotes rapid dissociation of the class 1 termination factor
2014
KS Koutmou, ME McDonald, JL Brunelle, R Green
RNA
The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer
2011
KS Koutmou, JJ Day-Storms, CA Fierke
RNA
A divalent cation stabilizes the active conformation of the B. subtilis RNase P•pre-tRNA complex: a role for an inner-sphere metal ion in RNase P
2010
J Hsieh, KS Koutmou, D Rueda, M Koutmos, NG Walter, CA Fierke
Journal of Molecular Biology
NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P
2010
KS Koutmou, A Casiano-Negroni, M Getz, S Paczini, AJ Andrews, JE Penner-Hahn, HM Al-Hashimi, CA Fierke
Proceedings of the National Academy of Sciences
Protein–precursor tRNA contact leads to sequence-specific recognition of 5′ leaders by bacterial ribonuclease P
2010
KS Koutmou, NH Zahler, JC Kurz, FE Campbell, ME Harris, CA Fierke
Journal of Molecular Biology
Kinetic mechanism of bacterial RNase P
2009
KS Koutmou, J Hsieh, CA Fierke
Protein Reviews, Volume 10: Ribonuclease P (book chapter)
Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis
2007
JK Smith, J Hsieh, CA Fierke
Biopolymers