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METHYLATED GUANOSINE AND URIDINE MODIFICATIONS IN S. CEREVISIAE MRNAS MODULATE TRANSLATION
2023
JD Jones, MK Franco, TJ Smith, LR Snyder, A Anders, BT Ruotolo, RT Kennedy, KS Koutmou
RSC ChemBio (DOI: 10.1039/D2CB00229A)
NUCLEASE P1 DIGESTION FOR BOTTOM-UP RNA SEQUENCING OF MODIFIED SIRNA THERAPEUTICS
2023
JD Jones, K Grassmyer, RT Kennedy, KS Koutmou, T Maloney
Analytical Chemistry (DOI: 10.1021/acs.analchem.2c04902)
ANTICODON STEM-LOOP TRNA MODIFICATIONS INFLUENCE CODON DECODING AND FRAME MAINTENANCE DURING TRANSLATION
2022
TJ Smith, R Giles and KS Koutmou
submitted, under revision
N1-METHYLPSEUDOURIDINE AND PSEUDOURIDINE MODIFICATIONS IMPACT AMINO ACID MISINCORPORATION DURING TRANSLATION
2022
JG Monroe, L Mitchell, I Deb, B Roy, AZ Frank, KS Koutmou
submitted, under revision (pre-print on bioRxiv DOI: 10.1101/2022.06.13.495988)
A HUMANIZED YEAST MODEL REVEALS DOMINANT-NEGATIVE PROPERTIES OF NEUROPATHY-ASSOCIATED ALANYL-TRNA SYNTHETASE MUTATIONS
2022
R Meyer-Schuman, S Marte, TJ Smith, S Feely, M Kennerson, G Nicholson, M Shy, KS Koutmou, A Antonellis
submitted (pre-print on bioRxiv DOI: 10.1101/2022.05.25.493316)
SEQUENCE-SPECIFIC PROGRAMMABLE CAPTURE AND CONCENTRATION OF VIRAL RNA BY TYPE III CRISPR SYSTEM ENHANCES DIAGNOSTIC
2022
A Nemudraia, A Nemudryi, M Buyukyoruk, AM Scherffius, T Zahl, T Wiegand, S Pandey, J Nichols, L Hall, A McVey, HH Lee, R Wilkinson, LR Snyder, JD Jones, KS Koutmou, A Santiago-Frangos, B Wiedenheft
Nature Communications (DOI: 10.1038/s41467-022-35445-5)
MAPPING MRNA MODIFICATIONS FOR FUNCTIONAL STUDIES
2022
JD Jones, DE Eyler, KS Koutmou
Nature Biotechnology (DOI: 10.1038/s41587-022-01537-2)
SUPPORTING STUDENT LEARNING IN BIOCHEMISTRY USING A SCIENCE COMMUNICATION FOCUSED WRITING ASSIGNMENT
2022
SA Finkenstaedt-Quinn, NF Garza, CA Wilhelm, KS Koutmou, GV Shultz
Journal of Chemical Education (DOI: 10.1021/acs.jchemed.2c00171)
CGG REPEATS TRIGGER TRANSLATIONAL FRAMESHIFTING TO GENERATE AGGREGATION-PRONE CHIMERIC PROTEINS IN NEURONS
2022
SE Wright, CM Rodriguez, J Monroe, J Xing, A Krans, BN Flores, V Barsur, MI Ivanova, KS Koutmou, SJ Barmada, PK Todd
Nucleic Acids Research (DOI: 10.1093/nar/gkac626)
MRNA AND TRNA MODIFICATION STATES INFLUENCE RIBOSOME SPEED AND FRAME MAINTENANCE DURING POLY(LYSINE) PEPTIDE SYNTHESIS
2022
TJ Smith, M Tardu, HJ Khatri, KS Koutmou
Journal of Biological Chemistry (DOI: 10.1016/j.jbc.2022.102039)
***Selected as an Editor's Choice article
CHEMICAL MODIFICATIONS TO MRNA NUCLEOBASES IMPACT TRANSLATION ELONGATION AND TERMINATION
2022
MK Franco and KS Koutmou
Biophysical Chemistry (DOI: 10.1016/j.bpc.2022.106780)
***Article featured on the journal cover
THE CAMP SIGNALING PATHWAY REGULATES EPE1 PROTEIN LEVELS AND HETEROCHROMATIN ASSEMBLY
2022
S Jia, K Bao, CM Shan, X Chen, G Raiymbek, JG Monroe, KS Koutmou, K Ragunathan, C Lu, L Berchowitz
PLoS Genetics (DOI: 10.1371/journal.pgen.1010049)
PSEUDOURIDINE SYNTHASE 7 IS AN OPPORTUNISTIC ENZYME THAT BINDS AND MODIFIES SUBSTRATES WITH DIVERSE SEQUENCES AND STRUCTURES
2022
MK Purchal, DE Eyler, M Tardu, MK Franco, MM Korn, T Khan, R McNassor, R Giles, K Lev, H Sharma, J Monroe, L Mallik, M Koutmos, KS Koutmou
PNAS (DOI: 10.1073/pnas.2109708119)
IN VITRO INVESTIGATION OF TRANSLATIONAL FIDELITY ON MODIFIED CODONS
2021
JG Monroe, TJ Smith, KS Koutmou
Methods Enzymology (DOI: 10.1016/bs.mie.2021.06.011)
COMMUNICATING SCIENCE TO THE GENERAL PUBLIC THROUGH A BIOCHEMISTRY WRITING ASSIGNMENT
2021
Garza N, Finkenstaedt-Quinn S, Wilhelm, C, Koutmou K, Shultz G
Journal of Chemical Education (DOI: 10.1021/acs.jchemed.0c01176)
A MOLECULAR LEVEL PERSPECTIVE ON THE FREQUENCY, DISTRIBUTION AND POSSIBLE CELLULAR ROLES OF MRNA MODIFICATIONS
2020
JD Jones, J Monroe and KS Koutmou
WIREs RNA (DOI: 10.1002/wrna.1586)
***Recognized as a “top cited article 2020-2021” in WIREs RNA
PSEUDOURIDINYLATION OF MRNA CODING SEQUENCES ALTERS TRANSLATION
2019
DE Eyler, MK Franco, Z Batool, MZ Wu, ML Debuke, M Dobosz-Bartoszek, JD Jones, Y Polikanov, B Roy, KS Koutmou
PNAS (DOI: 10.1073/pnas.1821754116)
IDENTIFICATION AND QUANTIFICATION OF MODIFIED NUCLEOSIDES IN SACCHAROMYCES CEREVISIAE MRNAS
2019
M Tardu, JD Jones, RT Kennedy, Q Lin, KS Koutmou
ACS Chemical Biology (DOI: 10.1021/acschembio.9b00369)
SYNTHESIS AT THE SPEED OF CODONS
2015
KS Koutmou, A Radhakrishnan, R Green
Trends in Biomedical Sciences
TRANSLATIONAL CONTROL BY LYSINE-ENCODING A-RICH SEQUENCES
2015
L Arthur, S Pavlovic-Djuranovic, KS Koutmou, R Green, P Szczesny, S Djuranovic
Science Advances
SID-1 EXTRACELLULAR DOMAIN SELECTIVELY BINDS LONG DSRNA AND IS REQUIRED FOR RNA TRANSPORT BY SID-1
2015
W Li, KS Koutmou, DJ Leahy, M Li
Journal of Biological Chemistry
RIBOSOMES SLIDE ON LYSINE-ENCODING HOMOPOLYMERIC A STRETCHES
2015
KS Koutmou, AP Schuller, JL Brunelle, A Radhakrishnan, S Djuranovic, R Green
eLife
RF3:GTP PROMOTES RAPID DISSOCIATION OF THE CLASS 1 TERMINATION FACTOR
2014
KS Koutmou, ME McDonald, JL Brunelle, R Green
RNA
THE RNR MOTIF OF B. SUBTILIS RNASE P PROTEIN INTERACTS WITH BOTH PRNA AND PRE-TRNA TO STABILIZE AN ACTIVE CONFORMER
2011
KS Koutmou, JJ Day-Storms, CA Fierke
RNA
A DIVALENT CATION STABILIZES THE ACTIVE CONFORMATION OF THE B. SUBTILIS RNASE P•PRE-TRNA COMPLEX: A ROLE FOR AN INNER-SPHERE METAL ION IN RNASE P
2010
J Hsieh, KS Koutmou, D Rueda, M Koutmos, NG Walter, CA Fierke
Journal of Molecular Biology
NMR AND XAS REVEAL AN INNER-SPHERE METAL BINDING SITE IN THE P4 HELIX OF THE METALLO-RIBOZYME RIBONUCLEASE P
2010
KS Koutmou, A Casiano-Negroni, M Getz, S Paczini, AJ Andrews, JE Penner-Hahn, HM Al-Hashimi, CA Fierke
Proceedings of the National Academy of Sciences
PROTEIN–PRECURSOR TRNA CONTACT LEADS TO SEQUENCE-SPECIFIC RECOGNITION OF 5′ LEADERS BY BACTERIAL RIBONUCLEASE P
2010
KS Koutmou, NH Zahler, JC Kurz, FE Campbell, ME Harris, CA Fierke
Journal of Molecular Biology
KINETIC MECHANISM OF BACTERIAL RNASE P
2009
KS Koutmou, J Hsieh, CA Fierke
Protein Reviews, Volume 10: Ribonuclease P (book chapter)
IMPORTANCE OF RNA-PROTEIN INTERACTIONS IN BACTERIAL RIBONUCLEASE P STRUCTURE AND CATALYSIS
2007
JK Smith, J Hsieh, CA Fierke
Biopolymers